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Indeed, this study demonstrates that inhibiting Gβγ in TCR-stimulated CD4+ T helper cells decreases levels of mRNAs encoding IFN-γ and ILA. .
Results: Gallein and Gβ1 siRNA decreased interferon-γ (IFN-γ) and ILA mRNA levels in TCR-stimulated CD4+ T cells grown under TH1-promoting.
Brabet P, Boulay G, Bradley A, Birnbaumer L.
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